For research use only. Not for therapeutic Use.
Murizatoclax, also known as AMG-397, is a potent and selective MCL-1 inhibitor. AMG 397 targets and binds to Mcl-1, thereby preventing the binding of Mcl-1 to and inactivation of certain pro-apoptotic proteins. This promotes apoptosis of cells overexpressing Mcl-1. Mcl-1, an anti-apoptotic protein belonging to the B-cell lymphoma 2 (Bcl-2) family of proteins, is upregulated in cancer cells and promotes tumor cell survival.
Catalog Number | I032893 |
CAS Number | 2245848-05-7 |
Synonyms | AMG-397; AMG397; AMG397; Murizatoclax; |
Molecular Formula | C42H57ClN4O5S |
Purity | 98% |
Target | Bcl-2 Family |
Solubility | Soluble in DMSO |
Appearance | Solid powder |
Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
IUPAC Name | (13S,31R,32R,4R,5E,8S,9R)-6'-chloro-4-methoxy-8,9-dimethyl-4-{[(9aR)-octahydro-2H-pyrido[1,2-a]pyrazin-2-yl]methyl}-3',4'-dihydro-12H,14H,2'H-spiro[10λ6-thia-11-aza-1(5,7)-[1,5]benzoxazepina-3(1,2)-cyclobutanacyclododecaphan-5-ene-13,1'-naphthalene]-10,10,12-trione |
InChI | InChI=1S/C42H57ClN4O5S/c1-29-8-6-18-42(51-3,27-45-20-21-46-19-5-4-10-35(46)25-45)37-14-11-33(37)24-47-26-41(17-7-9-31-22-34(43)13-15-36(31)41)28-52-39-16-12-32(23-38(39)47)40(48)44-53(49,50)30(29)2/h6,12-13,15-16,18,22-23,29-30,33,35,37H,4-5,7-11,14,17,19-21,24-28H2,1-3H3,(H,44,48)/b18-6+/t29-,30+,33-,35+,37+,41+,42-/m0/s1 |
InChIKey | BJTFTQIBRVBSBH-VEYPSBGLSA-N |
SMILES | [H][C@@]1([C@@](CN2C[C@]3(CCCCN3CC2)[H])(/C=C/C[C@@H]([C@H](S(=O)(NC4=O)=O)C)C)OC)CC[C@H]1CN5C[C@]6(COC7=C5C=C4C=C7)C8=CC=C(Cl)C=C8CCC6 |