Murizatoclax

• CAT Number: I032893
• CAS Number: 2245848-05-7
• Molecular Formula: C42H57ClN4O5S
• Molecular Weight: 765.45
• Purity: 98%
• Synonyms: AMG-397; AMG397; AMG397; Murizatoclax
• Target: Bcl-2 Family
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: (13S,31R,32R,4R,5E,8S,9R)-6'-chloro-4-methoxy-8,9-dimethyl-4-{[(9aR)-octahydro-2H-pyrido[1,2-a]pyrazin-2-yl]methyl}-3',4'-dihydro-12H,14H,2'H-spiro[10λ6-thia-11-aza-1(5,7)-[1,5]benzoxazepina-3(1,2)-cyclobutanacyclododecaphan-5-ene-13,1'-naphthalene]-10,10,12-trione
• InChI: InChI=1S/C42H57ClN4O5S/c1-29-8-6-18-42(51-3,27-45-20-21-46-19-5-4-10-35(46)25-45)37-14-11-33(37)24-47-26-41(17-7-9-31-22-34(43)13-15-36(31)41)28-52-39-16-12-32(23-38(39)47)40(48)44-53(49,50)30(29)2/h6,12-13,15-16,18,22-23,29-30,33,35,37H,4-5,7-11,14,17,19-21,24-28H2,1-3H3,(H,44,48)/b18-6+/t29-,30+,33-,35+,37+,41+,42-/m0/s1
• InChIKey: BJTFTQIBRVBSBH-VEYPSBGLSA-N
• SMILES: [H][C@@]1([C@@](CN2C[C@]3(CCCCN3CC2)[H])(/C=C/C[C@@H]([C@H](S(=O)(NC4=O)=O)C)C)OC)CC[C@H]1CN5C[C@]6(COC7=C5C=C4C=C7)C8=CC=C(Cl)C=C8CCC6

Murizatoclax(CAT: I032893) is a potent and selective inhibitor of the anti-apoptotic B-cell lymphoma 2 (Bcl-2) family proteins, playing a critical role in regulating programmed cell death. It is widely used in cancer research to investigate mechanisms of apoptosis and develop targeted therapies for malignancies where Bcl-2 overexpression contributes to tumor progression and treatment resistance. Murizatoclax facilitates studies on cell survival, drug resistance, and therapeutic combinations in hematological and solid tumors. With high specificity and robust activity, it is ideal for in vitro and in vivo studies, supporting the development of innovative strategies to restore apoptotic balance in cancer cells.