Muscarine iodide

• CAT Number: R046222
• CAS Number: 24570-49-8
• Molecular Formula: C9H20INO2
• Molecular Weight: 301.17
• Purity: ≥95%
• Synonyms: [(2S,4R,5S)-4-hydroxy-5-methyloxolan-2-yl]methyl-trimethylazanium;iodide
• InChI: InChI=1S/C9H20NO2.HI/c1-7-9(11)5-8(12-7)6-10(2,3)4;/h7-9,11H,5-6H2,1-4H3;1H/q+1;/p-1/t7-,8-,9+;/m0./s1
• InChIKey: PMFYONXEPDMBPE-CTERPIQNSA-M
• SMILES: CC1C(CC(O1)C[N+](C)(C)C)O.[I-]

Muscarine ((+)-Muscarine) iodide is a toxin that can stimulate the parasympathetic nervous system. Muscarine iodide is a prototype muscarinic acetylcholine receptor agonist[1][2].
Muscarine iodide administration (100 µM) induces an intracellular calcium signal amplitude similar to the one triggered by 10 µM ACh[1].Muscarine iodide (1-30 μM) produces a dose-dependent hyperpolarization in a sub-population of the NRM cells that contain 5-hydroxytryptamine (5-HT) on the NRM neurons[2].

Reference

[1]. Beatrice Mihaela Radu, et al. All muscarinic acetylcholine receptors (M 1-M 5) are expressed in murine brain microvascular endothelium. Sci Rep. 2017 Jul 11;7(1):5083.
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[2]. Z Z Pan, et al. Muscarine hyperpolarizes a subpopulation of neurons by activating an M2 muscarinic receptor in rat nucleus raphe magnus in vitro. J Neurosci. 1994 Mar;14(3 Pt 1):1332-8.
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