MUT056399

• CAT Number: I001078
• CAS Number: 1269055-85-7
• Molecular Formula: C15H13F2NO3
• Molecular Weight: 293.27
• Purity: ≥95%
• Target: Bacterial
• Solubility: DMSO: ≥ 31 mg/mL
• Storage: Store at -20°C
• IC50: 12 nM (for S. aureus), 58 nM (for E. coli) [1]
• IUPAC Name: 4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluorobenzamide
• InChI: InChI=1S/C15H13F2NO3/c1-2-8-6-12(19)14(7-10(8)16)21-13-4-3-9(15(18)20)5-11(13)17/h3-7,19H,2H2,1H3,(H2,18,20)
• InChIKey: QUHARGDBJJUOEB-UHFFFAOYSA-N
• SMILES: CCC1=CC(=C(C=C1F)OC2=C(C=C(C=C2)C(=O)N)F)O

MUT056399（Cat No.:I001078）, also known as Fab-001, is a potent inhibitor targeting the FabI enzyme, a key component in bacterial fatty acid synthesis. This compound shows significant activity against various Staphylococcus aureus strains, including methicillin-resistant (MRSA) and multidrug-resistant variants, with MIC90 values from 0.03 to 0.12 μg/ml. In vivo studies have demonstrated its effectiveness, protecting mice from lethal infections when administered subcutaneously at doses between 19.3 and 49.6 mg/kg/day. MUT056399 offers promising potential in combating resistant bacterial infections, contributing to advancements in antimicrobial research and treatment.

Reference

[1]. Escaich S, et al. The MUT056399 inhibitor of FabI is a new antistaphylococcal compound. Antimicrob Agents Chemother. 2011 Oct;55(10):4692-7.
[2]. Schiebel J, et al. An ordered water channel in Staphylococcus aureus FabI: unraveling the mechanism of substrate recognitionand reduction. Biochemistry. 2015 Mar 17;54(10):1943-55.