Mutagenic Impurity of Tenofovir Disoproxil

• CAT Number: I013752
• CAS Number: 1446486-33-4
• Molecular Formula: C₈H₉N₅
• Molecular Weight: 175.19
• Purity: ≥95%
• Target: HIV
• Solubility: DMSO: ≥ 29 mg/mL
• IUPAC Name: 9-[(E)-prop-1-enyl]purin-6-amine
• InChI: InChI=1S/C8H9N5/c1-2-3-13-5-12-6-7(9)10-4-11-8(6)13/h2-5H,1H3,(H2,9,10,11)/b3-2+
• InChIKey: ACWCANXGLNLMJB-NSCUHMNNSA-N
• SMILES: C/C=C/N1C=NC2=C(N=CN=C21)N

Mutagenic Impurity of Tenofovir Disoproxil（Cat No.:I013752）is a potential byproduct formed during the synthesis of tenofovir disoproxil, an antiviral used in HIV and hepatitis B treatment. This impurity, identified through rigorous testing, poses concerns due to its mutagenic properties, which could potentially cause genetic mutations. Regulatory agencies require comprehensive testing to assess the impurity’s concentration and its potential risks. Ensuring that the impurity level is below the established safety limits is crucial to maintaining the safety and efficacy of the drug in clinical use.