Mutanocyclin

• CAT Number: I041050
• CAS Number: 875455-92-8
• Molecular Formula: C10H15NO3
• Molecular Weight: 197.23
• Purity: ≥95%
• Synonyms: (2R)-4-acetyl-3-hydroxy-2-(2-methylpropyl)-1,2-dihydropyrrol-5-one
• InChI: InChI=1S/C10H15NO3/c1-5(2)4-7-9(13)8(6(3)12)10(14)11-7/h5,7,13H,4H2,1-3H3,(H,11,14)/t7-/m1/s1
• InChIKey: SHHAXAUQMPMPRV-SSDOTTSWSA-N
• SMILES: CC(C)CC1C(=C(C(=O)N1)C(=O)C)O

Mutanocyclin is a potent antifungal agent. Mutanocyclin inhibits Candida albicans (C. albicans) filamentation. Mutanocyclin decreases the mRNA expression of HWP1, ECE1, FLO8, TEC1. Mutanocyclin inhibits yeast-form in ex vivo mouse[1].
Mutanocyclin (8, 16, 32 µg/mL, 24, 36 h) inhibits Candida albicans (C. albicans) filamentation in a dose-dependent manner[1].
Mutanocyclin (32 µg/mL) decreases the mRNA expression of HWP1, ECE1, FLO8, TEC1 in C. albicans cells[1].
Mutanocyclin functions by regulating the PKA catabolic subunit Tpk2 and its preferential binding target Sfl1[1].
Mutanocyclin (32 µg/mL; 24 h infects tongues of mouse) inhibits yeast-form in ex vivo mouse tongue infection models of C. albicans[1].
Mutanocyclin (6.4, 12.8, 25.6 µg/mL; 48 h) attenuates the virulence of C. albicans in the G. mellonella infection model[1].

Reference

[1]. Tao L, et al. Streptococcus mutans suppresses filamentous growth of Candida albicans through secreting mutanocyclin, an unacylated tetramic acid. Virulence. 2022 Dec;13(1):542-557.
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