For research use only. Not for therapeutic Use.
<p style=/line-height:25px/>Mutant IDH1 Inhibitor is a potent mutant IDH1 R132H inhibitor with IC50 of < 72 nM.<br>IC50 value: < 72 nM [1]<br>Target: mutant IDH1 R132H<br>More information can be found in Patent WO 2013046136 A1 20130404 (Example 556)<br>3-Pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH and their preparation<br>By Cho, Young Shin; Levell, Julian Roy; Toure, Bakary-Barry; Yang, Fan; Caferro, Thomas;<br><br>Lei, Huangshu; Lenoir, Francois; Liu, Gang; Palermo, Mark G.; Shultz, Michael David; et al<br>From PCT Int. Appl. (2013), WO 2013046136 A1 20130404.<br></p>
| Catalog Number | I001646 |
| CAS Number | 1429180-08-4 |
| Synonyms | (S)-3-(2-(((S)-1-(4-((4-acetylpiperazin-1-yl)methyl)phenyl)ethyl)amino)pyrimidin-4-yl)-4-isopropyloxazolidin-2-one |
| Molecular Formula | C25H34N6O3 |
| Purity | ≥95% |
| Target | Isocitrate Dehydrogenase (IDH) |
| Solubility | DMSO: ≥ 34 mg/mL |
| Storage | Store at -20C |
| IC50 | < 72 nM [1] |
| IUPAC Name | (4S)-3-[2-[[(1S)-1-[4-[(4-acetylpiperazin-1-yl)methyl]phenyl]ethyl]amino]pyrimidin-4-yl]-4-propan-2-yl-1,3-oxazolidin-2-one |
| InChI | InChI=1S/C25H34N6O3/c1-17(2)22-16-34-25(33)31(22)23-9-10-26-24(28-23)27-18(3)21-7-5-20(6-8-21)15-29-11-13-30(14-12-29)19(4)32/h5-10,17-18,22H,11-16H2,1-4H3,(H,26,27,28)/t18-,22+/m0/s1 |
| InChIKey | BEWLUEOYYPKPQL-PGRDOPGGSA-N |
| SMILES | CC(C)C1COC(=O)N1C2=NC(=NC=C2)NC(C)C3=CC=C(C=C3)CN4CCN(CC4)C(=O)C |
| Reference | <p style=/line-height:25px/> |
