Muzolimine

• CAT Number: I008217
• CAS Number: 55294-15-0
• Molecular Formula: C11H11Cl2N3O
• Molecular Weight: 272.13
• Purity: ≥95%
• Synonyms: Muzolimina; Muzoliminum; Edrul; Muzolimine;3-amino-1-(1-(3,4-dichlorophenyl)ethyl)-1H-pyrazol-5(4H)-one
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: 5-amino-2-[1-(3,4-dichlorophenyl)ethyl]-4H-pyrazol-3-one
• InChI: InChI=1S/C11H11Cl2N3O/c1-6(16-11(17)5-10(14)15-16)7-2-3-8(12)9(13)4-7/h2-4,6H,5H2,1H3,(H2,14,15)
• InChIKey: RLWRMIYXDPXIEX-UHFFFAOYSA-N
• SMILES: CC(C1=CC(=C(C=C1)Cl)Cl)N2C(=O)CC(=N2)N

Muzolimine(CAT: I008217) is a potent loop diuretic primarily used in renal and cardiovascular research. It inhibits the sodium-potassium-chloride symporter (NKCC2) in the thick ascending limb of the loop of Henle, leading to enhanced excretion of sodium, potassium, chloride, and water. This mechanism makes it a valuable tool for studying conditions like hypertension, edema, and heart failure. Muzolimine is particularly useful for exploring electrolyte balance, renal function, and diuretic resistance in disease models. Its unique pharmacological properties also aid in investigating the therapeutic potential of loop diuretics in managing fluid retention and cardiovascular complications.