Muzolimine

• CAT Number: I008217
• CAS Number: 55294-15-0
• Molecular Formula: C11H11Cl2N3O
• Molecular Weight: 272.129
• Purity: ≥95%
• Synonyms: Muzolimina; Muzoliminum; Edrul; Muzolimine;3-amino-1-(1-(3,4-dichlorophenyl)ethyl)-1H-pyrazol-5(4H)-one
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: 5-amino-2-[1-(3,4-dichlorophenyl)ethyl]-4H-pyrazol-3-one
• InChI: InChI=1S/C11H11Cl2N3O/c1-6(16-11(17)5-10(14)15-16)7-2-3-8(12)9(13)4-7/h2-4,6H,5H2,1H3,(H2,14,15)
• InChIKey: RLWRMIYXDPXIEX-UHFFFAOYSA-N
• SMILES: CC(C1=CC(=C(C=C1)Cl)Cl)N2C(=O)CC(=N2)N

Muzolimine is a loop diuretic primarily used in research focused on managing conditions such as hypertension and edema associated with heart failure, kidney disorders, and liver cirrhosis. It works by inhibiting sodium and chloride reabsorption in the kidneys’ loop of Henle, promoting the excretion of water and electrolytes. This leads to increased urine output and reduced fluid retention. Muzolimine was studied for its potential advantages over other diuretics due to its longer duration of action, but its clinical use has been limited because of concerns over adverse side effects like nephrotoxicity.