MW-150

• CAT Number: I019187
• CAS Number: 1628502-91-9
• Molecular Formula: C₂₄H₂₃N₅
• Molecular Weight: 381.47
• Purity: ≥95%
• Target: p38 MAPK; Autophagy
• IUPAC Name: 6-(4-methylpiperazin-1-yl)-3-naphthalen-2-yl-4-pyridin-4-ylpyridazine
• InChI: InChI=1S/C24H23N5/c1-28-12-14-29(15-13-28)23-17-22(19-8-10-25-11-9-19)24(27-26-23)21-7-6-18-4-2-3-5-20(18)16-21/h2-11,16-17H,12-15H2,1H3
• InChIKey: CIIVUDIZZJLXCN-UHFFFAOYSA-N
• SMILES: CN1CCN(CC1)C2=NN=C(C(=C2)C3=CC=NC=C3)C4=CC5=CC=CC=C5C=C4

MW-150（Cat No.:I019187）is a selective, small-molecule inhibitor of p38α MAPK, specifically designed to reduce neuroinflammation by targeting overactive p38 MAPK signaling. It has been studied in preclinical models for its potential to mitigate neurodegenerative diseases, including Alzheimer’s disease, traumatic brain injury, and multiple sclerosis. By inhibiting p38α MAPK, MW-150 decreases the production of pro-inflammatory cytokines, thus protecting neurons from inflammation-induced damage. Its neuroprotective properties make it a promising compound for exploring therapeutic strategies aimed at reducing inflammation and oxidative stress in neurodegenerative and neuroinflammatory conditions.

Reference

[1]. Roy SM, et al. Targeting human central nervous system protein kinases: An isoform selective p38αMAPK inhibitor that attenuates disease progression in Alzheimer’s disease mouse models. ACS Chem Neurosci. 2015 Apr 15;6(4):666-80.