MYCi361 (Cat No.:I017779) is an MYC inhibitor that binds to intracellular MYC, disrupts MYC/MAX dimers, and impairs MYC-driven gene expression. MYCi361 can bind to MYC with a corresponding Kd value of 3.2 μM. MYCi361 inhibits tumor growth in vivo, increases tumor immune cell infiltration, upregulates PD-L1 on tumors, and sensitizes tumors to anti-PD1 immunotherapy.
| Catalog Number | I017779 |
| CAS Number | 2289690-31-7 |
| Molecular Formula | C₂₆H₁₆ClF₉N₂O₂ |
| Purity | ≥95% |
| Storage | 2-8°C |
| IUPAC Name | 2-[3,5-bis(trifluoromethyl)phenyl]-3-[(4-chlorophenyl)methoxy]-6-[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]phenol |
| InChI | InChI=1S/C26H16ClF9N2O2/c1-38-19(11-21(37-38)26(34,35)36)18-6-7-20(40-12-13-2-4-17(27)5-3-13)22(23(18)39)14-8-15(24(28,29)30)10-16(9-14)25(31,32)33/h2-11,39H,12H2,1H3 |
| InChIKey | CKLCWLSEYDDTCN-UHFFFAOYSA-N |
| SMILES | CN1C(=CC(=N1)C(F)(F)F)C2=C(C(=C(C=C2)OCC3=CC=C(C=C3)Cl)C4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F)O |
| Reference | [1]. Han H, et al. Small-Molecule MYC Inhibitors Suppress Tumor Growth and Enhance Immunotherapy. Cancer Cell. 2019 Nov 11;36(5):483-497.e15. |
