MYCi975

• CAT Number: I017778
• CAS Number: 2289691-01-4
• Molecular Formula: C25H16Cl2F6N2O2
• Molecular Weight: 561.3
• Purity: ≥95%
• Storage: 3 years -20°C powder
• SMILES: CN1C(=CC(=N1)C(F)(F)F)C2=C(C(=C(C=C2)OCC3=CC=C(C=C3)Cl)C4=CC(=C(C=C4)Cl)C(F)(F)F)O

MYCi975 (NUCC-0200975) is a potent, selective and orally active inhibitor of MYC that disrupts MYC/MAX interaction, promotes MYC T58 phosphorylation and MYC degradation, and impairs MYC driven gene expression. MYCi975 exhibits potent anti-tumor activities.

Reference

[1] Huiying Han, et al. Cancer Cell. 2019 Nov 11;36(5):483-497.e15.
[2] Hikita T, et al. Cancer Sci. 2022 Apr;113(4):1264-1276.
[3] Liu S, et al. Oncoimmunology. 2022 Sep 30;11(1):2130583.