Mycophenolic acid

• CAT Number: A000307
• CAS Number: 24280-93-1
• Molecular Formula: C17H20O6
• Molecular Weight: 320.3
• Purity: ≥95%
• Synonyms: 24280-93-1; Mycophenolate; Melbex; Myfortic; Mycophenolsaeure
• Target: Anti-infection
• Storage: -20°C
• InChI: 1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+
• InChIKey: HPNSFSBZBAHARI-RUDMXATFSA-N
• SMILES: CC1=C(C(=C(C2=C1COC2=O)O)CC=C(C)CCC(=O)O)OC

Mycophenolic acid is an immunosuppressant drug used to prevent rejection in organ transplantation. It inhibits an enzyme needed for the growth of T cells and B cells. It was initially marketed as the prodrug mycophenolate mofetil (MMF) to improve oral bioavailability.

Reference

1: Iboshi H, Yamaguchi H, Suzuki H, Kikuchi M, Tanaka M, Takasaki S, Takahashi A,
Maekawa M, Shimada M, Matsuda Y, Okada Y, Mano N. Development of a Liquid
Chromatography Tandem Mass Spectrometric Method for Quantification of
Mycophenolic Acid and Its Glucuronides in Dried Blood Spot Samples. Ther Drug
Monit. 2017 Oct 14. doi: 10.1097/FTD.0000000000000458. [Epub ahead of print]
PubMed PMID: 29040229.

2: Yoshimura K, Yano I, Yamamoto T, Kawanishi M, Isomoto Y, Yonezawa A, Kondo T,
Takaori-Kondo A, Matsubara K. Population pharmacokinetics and pharmacodynamics of
mycophenolic acid using the prospective data in patients undergoing hematopoietic
stem cell transplantation. Bone Marrow Transplant. 2017 Oct 9. doi:
10.1038/bmt.2017.213. [Epub ahead of print] PubMed PMID: 28991252.

3: Gaies E, Ben Sassi M, El Jebari H, Jebabli N, Charfi R, Chokri I, Salouage I,
Klouz A, Trabelsi S. Limited sampling strategy for the estimation of mycophenolic
acid area under the curve in Tunisian renal transplant patients. Nephrol Ther.
2017 Nov;13(6):460-462. doi: 10.1016/j.nephro.2017.02.010. Epub 2017 Sep 22.
PubMed PMID: 28958670.

4: Slovak JE, Rivera SM, Hwang JK, Court MH, Villarino NF. Pharmacokinetics of
Mycophenolic Acid after Intravenous Administration of Mycophenolate Mofetil to
Healthy Cats. J Vet Intern Med. 2017 Sep 11. doi: 10.1111/jvim.14827. [Epub ahead
of print] PubMed PMID: 28892209.

5: Fernández-Ramos AA, Marchetti-Laurent C, Poindessous V, Antonio S, Petitgas C,
Ceballos-Picot I, Laurent-Puig P, Bortoli S, Loriot MA, Pallet N. A comprehensive
characterization of the impact of mycophenolic acid on the metabolism of Jurkat T
cells. Sci Rep. 2017 Sep 5;7(1):10550. doi: 10.1038/s41598-017-10338-6. PubMed
PMID: 28874730; PubMed Central PMCID: PMC5585210.

6: Kiang TKL, Ensom MHH. Population Pharmacokinetics of Mycophenolic Acid: An
Update. Clin Pharmacokinet. 2017 Aug 31. doi: 10.1007/s40262-017-0593-6. [Epub
ahead of print] Review. PubMed PMID: 28861847.

7: Parant F, Ranchin B, Gagnieu MC. The Roche Total Mycophenolic Acid® assay: An
application protocol for the ABX Pentra 400 analyzer and comparison with LC-MS in
children with idiopathic nephrotic syndrome. Pract Lab Med. 2017 Jan 4;7:19-26.
doi: 10.1016/j.plabm.2016.12.002. eCollection 2017 Apr. PubMed PMID: 28856214;
PubMed Central PMCID: PMC5575364.

8: Gaillard J, Rotman S, Girardet C, Spertini F. Successful therapy with
mycophenolic acid in a membranous glomerulonephritis due to Kimura disease
. Clin
Nephrol. 2017 Oct;88(10):221-225. doi: 10.5414/CN109086. PubMed PMID: 28853699.

9: Feld JJ, Pawlotsky JM, Tatsch F, Sulkowski M, Poordad F, Jacobson I. Response
to Cytoplasmic rods and rings in ribavirin and Cytoplasmic rods and rings in
mycophenolic acid treatment. Liver Int. 2017 Nov;37(11):1743-1744. doi:
10.1111/liv.13567. PubMed PMID: 28853201.

10: Yu ZC, Zhou PJ, Wang XH, Françoise B, Xu D, Zhang WX, Chen B. Population
pharmacokinetics and Bayesian estimation of mycophenolic acid concentrations in
Chinese adult renal transplant recipients. Acta Pharmacol Sin. 2017
Nov;38(11):1566-1579. doi: 10.1038/aps.2017.115. Epub 2017 Aug 24. PubMed PMID:
28836585.