For research use only. Not for therapeutic Use.
MyD88-IN-1 is a potent MyD88 inhibitor. MyD88-IN-1 inhibits the interaction of TLR4 and MyD88 and suppressed the NF-κB pathway. MyD88-IN-1 can be used in research of cancer and inflammatory[1].
| Catalog Number | I041091 |
| CAS Number | 2911609-80-6 |
| Synonyms | N-(6-methoxypyridin-3-yl)-3-nitro-4-[4-[(3-nitrophenyl)methyl]piperazin-1-yl]benzenesulfonamide |
| Molecular Formula | C23H24N6O7S |
| Purity | ≥95% |
| InChI | InChI=1S/C23H24N6O7S/c1-36-23-8-5-18(15-24-23)25-37(34,35)20-6-7-21(22(14-20)29(32)33)27-11-9-26(10-12-27)16-17-3-2-4-19(13-17)28(30)31/h2-8,13-15,25H,9-12,16H2,1H3 |
| InChIKey | LDKDGYNCHLGOIP-UHFFFAOYSA-N |
| SMILES | COC1=NC=C(C=C1)NS(=O)(=O)C2=CC(=C(C=C2)N3CCN(CC3)CC4=CC(=CC=C4)[N+](=O)[O-])[N+](=O)[O-] |
| Reference | [1]. Chen P, et, al. Design, Synthesis, and Bioevaluation of Novel MyD88 Inhibitor c17 against Acute Lung Injury Derived from the Virtual Screen. J Med Chem. 2023 May 25;66(10):6938-6958. |
