For research use only. Not for therapeutic Use.
MYF-03-176（Cat No.:I043519）is a potent and selective small-molecule antagonist of the mineralocorticoid receptor (MR), a nuclear receptor involved in regulating sodium balance, blood pressure, and inflammation. By blocking MR activation, MYF-03-176 inhibits the effects of aldosterone, making it a promising candidate for the treatment of cardiovascular and renal disorders such as hypertension, heart failure, and chronic kidney disease. Unlike traditional steroidal MR antagonists, MYF-03-176 offers improved selectivity and reduced side effects. It is also a valuable tool for exploring MR signaling pathways and developing next-generation therapies targeting mineralocorticoid-driven pathologies.
| CAS Number | 2857937-59-6 |
| Synonyms | 2-fluoro-1-[(3R,4R)-3-(pyrimidin-2-ylamino)-4-[[4-(trifluoromethyl)phenyl]methoxy]pyrrolidin-1-yl]prop-2-en-1-one |
| Molecular Formula | C19H18F4N4O2 |
| Purity | ≥95% |
| IUPAC Name | 2-fluoro-1-[(3R,4R)-3-(pyrimidin-2-ylamino)-4-[[4-(trifluoromethyl)phenyl]methoxy]pyrrolidin-1-yl]prop-2-en-1-one |
| InChI | InChI=1S/C19H18F4N4O2/c1-12(20)17(28)27-9-15(26-18-24-7-2-8-25-18)16(10-27)29-11-13-3-5-14(6-4-13)19(21,22)23/h2-8,15-16H,1,9-11H2,(H,24,25,26)/t15-,16-/m1/s1 |
| InChIKey | KVAWNRUJSYWYJX-HZPDHXFCSA-N |
| SMILES | C=C(C(=O)N1C[C@H]([C@@H](C1)OCC2=CC=C(C=C2)C(F)(F)F)NC3=NC=CC=N3)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
