MYF-03-69

• CAT Number: I043520
• CAS Number: 2416418-11-4
• Molecular Formula: C22H20F3N5O2
• Molecular Weight: 443.42
• Purity: ≥95%
• Synonyms: 1-[(3R,4R)-3-(4-pyridin-3-yltriazol-1-yl)-4-[[4-(trifluoromethyl)phenyl]methoxy]pyrrolidin-1-yl]prop-2-en-1-one
• InChI: InChI=1S/C22H20F3N5O2/c1-2-21(31)29-12-19(30-11-18(27-28-30)16-4-3-9-26-10-16)20(13-29)32-14-15-5-7-17(8-6-15)22(23,24)25/h2-11,19-20H,1,12-14H2/t19-,20-/m1/s1
• InChIKey: AZGCPBIUNCLWPF-WOJBJXKFSA-N
• SMILES: C=CC(=O)N1CC(C(C1)OCC2=CC=C(C=C2)C(F)(F)F)N3C=C(N=N3)C4=CN=CC=C4

MYF-03-69 (TEAD-IN-3) is a potent and irreversible TEAD inhibitor. MYF-03-69 disrupts YAP-TEAD association, suppresses TEAD transcriptional activity and inhibits cell growth of Hippo signaling defective malignant pleural mesothelioma (MPM)[1].

Reference

[1]. Mengyang Fan, et al. Covalent disruptor of YAP-TEAD association suppresses defective Hippo signaling. Elife. 2022 Oct 27:11:e78810.
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