For research use only. Not for therapeutic Use.
Myosin V-IN-1 (compound 8) is a potent and selective Myosin V inhibitor, with a Ki of 6 μM. Myosin V-IN-1 shows acute inhibition of myosin V. Myosin V-IN-1 slows the actin-activated myosin V ATPase by specifically inhibiting ADP release from the actomyosin complex[1][2].
Myosin V-IN-1 (compound 8) shows dose-dependent reduction of the rate of steady-state actin-activated ATP hydrolysis by single-headed myosin V[1].
| Catalog Number | I041182 |
| CAS Number | 1259177-59-7 |
| Synonyms | 3-[[3-[[3-(4-morpholin-4-ylphenyl)-2H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]phenyl]methylsulfanyl]benzoic acid |
| Molecular Formula | C29H26N6O3S |
| Purity | ≥95% |
| InChI | InChI=1S/C29H26N6O3S/c36-28(37)21-4-2-6-24(16-21)39-18-19-3-1-5-22(15-19)31-29-30-17-25-26(33-34-27(25)32-29)20-7-9-23(10-8-20)35-11-13-38-14-12-35/h1-10,15-17H,11-14,18H2,(H,36,37)(H2,30,31,32,33,34) |
| InChIKey | JTMFLTNSCRPRHU-UHFFFAOYSA-N |
| SMILES | C1COCCN1C2=CC=C(C=C2)C3=C4C=NC(=NC4=NN3)NC5=CC=CC(=C5)CSC6=CC=CC(=C6)C(=O)O |
| Reference | [1]. Maschi D, et al. Myosin V Regulates Spatial Localization of Different Forms of Neurotransmitter Release in Central Synapses. Front Synaptic Neurosci. 2021 Apr 15;13:650334. [2]. Islam K, et al. A myosin V inhibitor based on privileged chemical scaffolds. Angew Chem Int Ed Engl. 2010 Nov 2;49(45):8484-8. |
