Myriocin

• CAT Number: R056414
• CAS Number: 35891-70-4
• Molecular Formula: C21H39NO6
• Molecular Weight: 401.54
• Purity: ≥95%
• Synonyms: (2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic Acid; [2S-(2R*,3S*,4S*,6E)]-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic Acid; (+)-Myriocin; ISP-I; NSC 177379; Thermozymocidin; (2S,3R,4R)-(E)-2-Amino-3,4-dih
• Target: HCV
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• IUPAC Name: (E,2S,3R,4R)-2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxoicos-6-enoic acid
• InChI: InChI=1S/C21H39NO6/c1-2-3-4-10-13-17(24)14-11-8-6-5-7-9-12-15-18(25)19(26)21(22,16-23)20(27)28/h9,12,18-19,23,25-26H,2-8,10-11,13-16,22H2,1H3,(H,27,28)/b12-9+/t18-,19+,21+/m1/s1
• InChIKey: ZZIKIHCNFWXKDY-GNTQXERDSA-N
• SMILES: CCCCCCC(=O)CCCCCC/C=C/C[C@H]([C@@H]([C@@](CO)(C(=O)O)N)O)O

Myriocin（Cat No.:R056414）is a potent, selective inhibitor of serine palmitoyltransferase (SPT), the key enzyme in sphingolipid biosynthesis. By inhibiting SPT, Myriocin reduces the production of sphingosine-1-phosphate (S1P) and other sphingolipids, which play crucial roles in cell growth, survival, and inflammation. This makes Myriocin valuable in studying sphingolipid metabolism and its involvement in various diseases, including cancer, neurodegenerative disorders, and autoimmune conditions. It is commonly used in research to explore the therapeutic potential of modulating sphingolipid pathways for the treatment of these diseases.

Reference

Myriocin, a new antifungal antibiotic from Myriococcum albomyces. Kluepfel D. J. Antibiot. 1972, 25, 109.Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin. Miyake Y. et al. , Biochem. Biophys. Res. Commun. 1995, 211, 396. Fungal metabolites. Part 12. Potent immunosuppressant, 14-deoxomyriocin, (2S,3R,4R)-(E)-2-amino-3,4-dihydroxy-2-hydroxymethyleicos-6-enoic acid and structure-activity relationships of myriocin derivatives. Fujita T. et al. , J. Biol. Chem. 2005, 280, 10284.