For research use only. Not for therapeutic Use.
Fungal antibiotic, atypic amino acid, immunomodulator, serine palmitoyltransferase inhibitor, apoptosis inducer.
| Catalog Number | R056414 |
| CAS Number | 35891-70-4 |
| Synonyms | (2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic Acid; [2S-(2R*,3S*,4S*,6E)]-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic Acid; (+)-Myriocin; ISP-I; NSC 177379; Thermozymocidin; (2S,3R,4R)-(E)-2-Amino-3,4-dih |
| Molecular Formula | C21H39NO6 |
| Purity | ≥95% |
| Target | Lipid Metabolism |
| Solubility | Soluble in DMSO |
| Storage | Store at -20°C |
| IUPAC Name | (E,2S,3R,4R)-2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxoicos-6-enoic acid |
| InChI | InChI=1S/C21H39NO6/c1-2-3-4-10-13-17(24)14-11-8-6-5-7-9-12-15-18(25)19(26)21(22,16-23)20(27)28/h9,12,18-19,23,25-26H,2-8,10-11,13-16,22H2,1H3,(H,27,28)/b12-9+/t18-,19+,21+/m1/s1 |
| InChIKey | ZZIKIHCNFWXKDY-GNTQXERDSA-N |
| SMILES | CCCCCCC(=O)CCCCCCC=CCC(C(C(CO)(C(=O)O)N)O)O |
| Reference | Myriocin, a new antifungal antibiotic from Myriococcum albomyces. Kluepfel D. J. Antibiot. 1972, 25, 109.<br/><br/>Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin. Miyake Y. et al. , Biochem. Biophys. Res. Commun. 1995, 211, 396. <br/><br/>Fungal metabolites. Part 12. Potent immunosuppressant, 14-deoxomyriocin, (2S,3R,4R)-(E)-2-amino-3,4-dihydroxy-2-hydroxymethyleicos-6-enoic acid and structure-activity relationships of myriocin derivatives. Fujita T. et al. , J. Biol. Chem. 2005, 280, 10284.</span></p> |
