Myristic Acid Alkyne

• CAT Number: R064400
• CAS Number: 82909-47-5
• Molecular Formula: C14H24O2
• Molecular Weight: 224.344
• Purity: ≥95%
• Synonyms: Alk-12;13-alkyne Myristic Acid
• Target: PROTAC Linkers
• Storage: -20°C
• IUPAC Name: tetradec-13-ynoic acid
• InChI: InChI=1S/C14H24O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h1H,3-13H2,(H,15,16)
• InChIKey: JNXXRQLAAJXERE-UHFFFAOYSA-N
• SMILES: C#CCCCCCCCCCCCC(=O)O

Myristic acid is a 14-<wbr></wbr>carbon saturated (14:0) fatty acid. In vivo, it is commonly added covalently to the N-<wbr></wbr>terminus of proteins in a co-<wbr></wbr>translational process termed N-<wbr></wbr>myristoylation. The sirtuin SIRT6 removes this acyl group from myristoylated TNF-<wbr></wbr>α, enhancing secretion. Myristic acid alkyne is a form of this myristic acid (Item No. 13351) with an ω-<wbr></wbr>terminal alkyne. Such terminal alkyne groups can be used in linking reactions, known as click chemistry, characterized by high dependability and specificity of azide-<wbr></wbr>alkyne bioconjugation reactions. Click chemistry has only recently been applied to the study of lipids.

Reference

1.Farazi, T.A.,Waksman, G., and Gordon, J.I. The biology and enzymology of protein N-myristoylation. The Journal of Biological Chemisty 276(43), 39501-39504 (2001).