N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride

• CAT Number: R007790
• CAS Number: 1177141-67-1
• Molecular Formula: C11H14Cl3N3O2S
• Molecular Weight: 358.66
• Purity: ≥95%
• Synonyms: CKI-7 Dihydrochloride
• Target: CK1
• Solubility: Soluble in DMSO > 10 mM
• Storage: Store at -20°C
• IUPAC Name: N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide;dihydrochloride
• InChI: InChI=1S/C11H12ClN3O2S.2ClH/c12-10-1-2-11(18(16,17)15-6-4-13)9-7-14-5-3-8(9)10;;/h1-3,5,7,15H,4,6,13H2;2*1H
• InChIKey: JUAVTXYOCISSSL-UHFFFAOYSA-N
• SMILES: C1=CC(=C2C=CN=CC2=C1S(=O)(=O)NCCN)Cl.Cl.Cl

N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide dihydrochloride（Cat No.:R007790）is a potent, cell-permeable inhibitor of protein kinase A (PKA) and other kinases, such as protein kinase G (PKG) and myosin light-chain kinase (MLCK). By inhibiting these enzymes, it disrupts phosphorylation pathways that regulate various cellular processes, including muscle contraction, cell signaling, and gene expression. This compound is widely used in biochemical research to study kinase-mediated pathways and their role in diseases such as cancer, cardiovascular disorders, and neurological conditions. Its selective kinase inhibition makes it a valuable tool for pharmacological studies.