N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide

• CAT Number: R020489
• CAS Number: 120615-25-0
• Molecular Formula: C11H12ClN3O2S
• Molecular Weight: 285.75
• Purity: ≥95%
• Synonyms: N-(2-Aminoethyl)-5-chloro-8-isoquinolinesulfonamide; CKI-7
• Storage: Store at −20°C
• IUPAC Name: N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide
• InChI: InChI=1S/C11H12ClN3O2S/c12-10-1-2-11(18(16,17)15-6-4-13)9-7-14-5-3-8(9)10/h1-3,5,7,15H,4,6,13H2
• InChIKey: OGKYMFFYOWUTKV-UHFFFAOYSA-N
• SMILES: C1=CC(=C2C=CN=CC2=C1S(=O)(=O)NCCN)Cl

N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide（Cat No.:R020489）is a potent protein kinase inhibitor, particularly targeting cyclic AMP-dependent protein kinase (PKA) and other serine/threonine kinases. This compound is commonly used in biochemical research to study signal transduction pathways, especially those involving PKA, which plays a crucial role in regulating cellular functions such as metabolism, gene expression, and apoptosis. Its inhibitory effects on kinase activity make it valuable for exploring the mechanisms of diseases like cancer and neurodegenerative disorders, as well as in the development of potential therapeutic strategies.