N-(5-Hydroxypentyl)maleimide

• CAT Number: I016348
• CAS Number: 180608-78-0
• Molecular Formula: C₉H₁₃NO₃
• Molecular Weight: 183.2
• Purity: ≥95%
• Target: ADC Linker
• IUPAC Name: 1-(5-hydroxypentyl)pyrrole-2,5-dione
• InChI: InChI=1S/C9H13NO3/c11-7-3-1-2-6-10-8(12)4-5-9(10)13/h4-5,11H,1-3,6-7H2
• InChIKey: YTIZONIKDWSRFR-UHFFFAOYSA-N
• SMILES: C1=CC(=O)N(C1=O)CCCCCO

N-(5-Hydroxypentyl)maleimide（Cat No.:I016348）is a non-cleavable linker that has the potential to be used in the synthesis of antibody-drug conjugates (ADCs), including Gemcitabine-O-Si(di-iso)-O-Mc (HY-130812). This linker is designed to provide stable and long-lasting covalent bonds between the antibody and drug molecules, allowing for targeted delivery of the therapeutic agent to specific cells or tissues. By utilizing N-(5-Hydroxypentyl)maleimide as a linker, the resulting ADCs may offer enhanced therapeutic efficacy and reduced systemic toxicity.

Reference

[1]. Finniss, M. C., et al. A versatile acid-labile linker for antibody–drug conjugates. Med. Chem. Commun., 2014, 5(9), 1355-1358.