N-563

• CAT Number: I001564
• CAS Number: 140686-92-6
• Molecular Formula: C15H29N5O5
• Molecular Weight: 359.42
• Purity: ≥95%
• Target: Fungal
• Solubility: physiological saline
• Storage: Store at -20°C
• IUPAC Name: 3-[[4-[7-(diaminomethylideneamino)heptanoylamino]-3-hydroxybutanoyl]amino]propanoic acid
• InChI: InChI=1S/C15H29N5O5/c16-15(17)19-7-4-2-1-3-5-12(22)20-10-11(21)9-13(23)18-8-6-14(24)25/h11,21H,1-10H2,(H,18,23)(H,20,22)(H,24,25)(H4,16,17,19)
• InChIKey: IFBKFXWWJPFRDV-UHFFFAOYSA-N
• SMILES: C(CCCN=C(N)N)CCC(=O)NCC(CC(=O)NCCC(=O)O)O

N-563（Cat No.:I001564）is a potent and selective inhibitor of the protein kinase C (PKC) family, specifically targeting the PKCθ isoform. This compound has shown promise in preclinical research for modulating immune responses, particularly in autoimmune diseases, by inhibiting T-cell activation and reducing inflammation. Its specificity for PKCθ makes it a valuable tool for investigating T-cell signaling pathways. Additionally, N-563 is being explored for its potential in cancer immunotherapy, where PKCθ plays a crucial role in tumor progression and immune evasion. Further studies are needed to assess its therapeutic potential in clinical settings.

Reference

[1]. Aoyagi K. et al.The novel immunostimulant N-563, an analogue of deoxyspergualin, promotes resistance to Candida albicans infection in mice.The Journal of Antibiotics.Oct;47(10):1077-83.doi:10.7164/antibiotics.47.1077(1994)