For research use only. Not for therapeutic Use.
N-Acetyl-D-mannosamine（Cat No.:R004638）is a naturally occurring monosaccharide derivative of mannose, often used in glycoscience research. It plays a crucial role in the biosynthesis of sialic acids, important components of glycoproteins and glycolipids that affect cell signaling, immune response, and cellular interactions. As a precursor to CMP-sialic acid, N-Acetyl-D-mannosamine is utilized in the study of glycosylation processes and the development of therapeutic strategies targeting sialylation. Its applications extend to research on infectious diseases, cancer, and neurodegenerative conditions, where sialic acid metabolism plays a key role in disease progression and therapeutic outcomes.
| Catalog Number | R004638 |
| CAS Number | 3615-17-6 |
| Synonyms | 2-(Acetylamino)-2-deoxy-D-mannopyranose; N-Acetylmannosamine? |
| Molecular Formula | C₈H₁₅NO₆ |
| Purity | ≥95% |
| Target | Metabolic Enzyme/Protease |
| Storage | -20°C |
| Reference | </br>1:Chronic administration of N-acetyl-D-mannosamine improves age-associated impairment of long-term potentiation in the senescence-accelerated mouse. Taniguchi S, Kuwahara M, Ito K.Neurosci Lett. 2015 Jun 26;598:41-6. doi: 10.1016/j.neulet.2015.05.011. Epub 2015 May 8. PMID: 25962821 </br>2:Crystal structure of product-bound complex of UDP-N-acetyl-d-mannosamine dehydrogenase from Pyrococcus horikoshii OT3. Pampa KJ, Lokanath NK, Girish TU, Kunishima N, Rai VR.Biochem Biophys Res Commun. 2014 Oct 24;453(3):662-7. doi: 10.1016/j.bbrc.2014.10.010. Epub 2014 Oct 8. PMID: 25305481 </br>3:Crystal structures and functional studies clarify substrate selectivity and catalytic residues for the unique orphan enzyme N-acetyl-D-mannosamine dehydrogenase. Sola-Carvajal A, Gil-Ortiz F, García-Carmona F, Rubio V, Sánchez-Ferrer Á.Biochem J. 2014 Sep 15;462(3):499-511. doi: 10.1042/BJ20140266. PMID: 24969681 </br>4:N-acetyl-D-mannosamine treatment alleviates age-related decline in place-learning ability in dogs. Nagasawa M, Shimozawa A, Mogi K, Kikusui T.J Vet Med Sci. 2014 May;76(5):757-61. Epub 2014 Jan 16. PMID: 24430654 Free PMC Article</br>5:Purification, crystallization and preliminary X-ray diffraction studies of a putative UDP-N-acetyl-D-mannosamine dehydrogenase from Pyrococcus horikoshii OT3. Lokanath NK, Pampa KJ, Kamiya T, Kunishima N.Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 May 1;63(Pt 5):412-4. Epub 2007 Apr 14. PMID: 17565184 Free PMC Article</br>6:Transport of N-acetyl-D-mannosamine and N-acetyl-D-glucosamine in Escherichia coli K1: effect on capsular polysialic acid production. Revilla-Nuin B, Reglero A, Martínez-Blanco H, Bravo IG, Ferrero MA, Rodríguez-Aparicio LB.FEBS Lett. 2002 Jan 30;511(1-3):97-101. PMID: 11821056 Free Article</br>7:Uptake of N-acetyl-D-mannosamine: an essential intermediate in polysialic acid biosynthesis by Escherichia coli K92. Revilla-Nuin B, Reglero A, Ferrero MA, Rodríguez-Aparicio LB.FEBS Lett. 1999 Apr 23;449(2-3):183-6. Erratum in: FEBS Lett 1999 Aug 13;456(3):417. PMID: 10338128 Free Article</br>8:Regulation of capsular polysialic acid biosynthesis by N-acetyl-D-mannosamine, an intermediate of sialic acid metabolism. Revilla-Nuin B, Rodriguez-Aparicio LB, Ferrero MA, Reglero A.FEBS Lett. 1998 Apr 17;426(2):191-5. PMID: 9599006 Free Article</br>9:Characterization of the gene cassette required for biosynthesis of the (alpha1–>6)-linked N-acetyl-D-mannosamine-1-phosphate capsule of serogroup A Neisseria meningitidis. Swartley JS, Liu LJ, Miller YK, Martin LE, Edupuganti S, Stephens DS.J Bacteriol. 1998 Mar;180(6):1533-9. PMID: 9515923 Free PMC Article</br>10:N-acetyl-D-neuraminic acid synthesis in Escherichia coli K1 occurs through condensation of N-acetyl-D-mannosamine and pyruvate. Rodríguez-Aparicio LB, Ferrero MA, Reglero A.Biochem J. 1995 Jun 1;308 ( Pt 2):501-5. PMID: 7772033 Free PMC Article |
