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Home > Reference Standards> > N-Acetyl-L-α-aspartyl-L-α-glutamyl-L-valyl-N-(4-nitrophenyl)-L-asparagine
189950-66-1-N-Acetyl-L-α-aspartyl-L-α-glutamyl-L-valyl-N-(4-nitrophenyl)-L-asparagine N-Acetyl-L-α-aspartyl-L-α-glutamyl-L-valyl-N-(4-nitrophenyl)-L-asparagine

N-Acetyl-L-α-aspartyl-L-α-glutamyl-L-valyl-N-(4-nitrophenyl)-L-asparagine

For research use only. Not for therapeutic Use.

  • CAT Number: R016689
  • CAS Number: 189950-66-1
  • Molecular Formula: C26H34N6O13
  • Molecular Weight: 638.6
  • Purity: ≥95%
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Related Small Molecules: 3-Methylsulfonyl-2,2/,4/,5,5/,6-hexachlorobiphenyl     Damascenone     benzyldimethyl(pentadecyl)ammonium chloride    

During apoptosis, activated caspase-<wbr></wbr>3 cleaves several substrates, including poly(ADP-<wbr></wbr>ribose) polymerase, which it specifically targets at the amino sequence DEVD. Ac-<wbr></wbr>DEVD-<wbr></wbr>pNA is a <em>para-<wbr></wbr></em>nitro aniline chromophore cleaved by caspases (K<sub>m</sub> = 18, 11, 32, 180, and 12 µM for caspases-<wbr></wbr>1, -<wbr></wbr>3, -<wbr></wbr>4, -<wbr></wbr>6, and -<wbr></wbr>7, respectively). It is not cleaved by caspase-<wbr></wbr>2. Cleavage is monitored colorimetrically at 405 nm.


Catalog Number R016689
CAS Number 189950-66-1
Synonyms

Ac-DEVD-pNA; N-Acetyl-Asp-Glu-Val-Asp-p-nitroanilide

Molecular Formula C26H34N6O13
Purity ≥95%
Target Caspase
Storage -20°C
InChIKey DAOMBBSDYYRHPX-ORGXJRBJSA-N

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