N-Acetyldesloratadine

For research use only. Not for therapeutic Use.

  • CAT Number: R040702
  • CAS Number: 117796-52-8
  • Molecular Formula: C21H21ClN2O
  • Molecular Weight: 352.86
  • Purity: ≥95%
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N-Acetyldesloratadine (SCH-37370) is a potent, orally active dual antagonist of platelet-activating factor (PAF) and histamine. N-Acetyldesloratadine inhibits PAF-induced aggregation of human platelets, with an IC50 of 0.6 µM[1].


Catalog Number R040702
CAS Number 117796-52-8
Synonyms

1-[4-(13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)piperidin-1-yl]ethanone

Molecular Formula C21H21ClN2O
Purity ≥95%
InChI InChI=1S/C21H21ClN2O/c1-14(25)24-11-8-15(9-12-24)20-19-7-6-18(22)13-17(19)5-4-16-3-2-10-23-21(16)20/h2-3,6-7,10,13H,4-5,8-9,11-12H2,1H3
InChIKey FLTBEMVEAFMWDD-UHFFFAOYSA-N
SMILES CC(=O)N1CCC(=C2C3=C(CCC4=C2N=CC=C4)C=C(C=C3)Cl)CC1
Reference

[1]. Billah MM, et, al. Discovery and preliminary pharmacology of Sch 37370, a dual antagonist of PAF and histamine. Lipids. 1991 Dec;26(12):1172-4.
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