For research use only. Not for therapeutic Use.
(+)-N-Allylnormetazocine ((+)-SKF 10047) hydrochloride is a benzomorphan opioid with psychotomi metic effects. (+)-N-Allylnormetazocine hydrochloride is an opioid receptor antagonist with Ki values of 300 nM and 27 μM for σ1 and σ2 opioid receptors, respectively. (+)-N-Allylnormetazocine hydrochloride can be used for the research of neurological disease[1][2].
(+)-N-Allylnormetazocine hydrochloride (1 nM) inhibits µ, δ and κ opioid receptors of 28.5%, 2.5% and 31%, respectively[1].
(+)-N-Allylnormetazocine hydrochloride shows Ki values of 300 nM and 27 μM for σ1 and σ2 opioid receptors[1].
(+)-N-Allylnormetazocine hydrochloride (0.3, 1, 3 , 10 and 30 mg/kg; intraperitoneal injection, 10 minutes before each session) dose-dependently increases the response made on the lever appropriate for dissociative anesthetics phencyclidine (PCP) in rats with PCP or saline[2].
| Catalog Number | R012862 |
| CAS Number | 133005-41-1 |
| Synonyms | (1S,9S)-1,13-dimethyl-10-prop-2-enyl-10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-4-ol;hydrochloride |
| Molecular Formula | C17H24ClNO |
| Purity | ≥95% |
| InChI | InChI=1S/C17H23NO.ClH/c1-4-8-18-9-7-17(3)12(2)16(18)10-13-5-6-14(19)11-15(13)17;/h4-6,11-12,16,19H,1,7-10H2,2-3H3;1H/t12?,16-,17-;/m0./s1 |
| InChIKey | ZTGMHFIGNYXMJV-XLIAGRDUSA-N |
| SMILES | CC1C2CC3=C(C1(CCN2CC=C)C)C=C(C=C3)O.Cl |
| Reference | [1]. May EL, et al. Synthesis and in vitro and in vivo activity of (-)-(1R,5R,9R)- and (+)-(1S,5S,9S)-N-alkenyl-, -N-alkynyl-, and -N-cyanoalkyl-5, 9-dimethyl-2′-hydroxy-6,7-benzomorphan homologues. J Med Chem. 2000 Dec 28;43(26):5030-6. [2]. Brady KT, et al. Stereoisomers of N-allylnormetazocine: phencyclidine-like behavioral effects in squirrel monkeys and rats. Science. 1982 Jan 8;215(4529):178-80. |
