For research use only. Not for therapeutic Use.
Arachidonoyl amides of both amino acids and neurotransmitters such as dopamine have been previously reported in the literature. N-<wbr></wbr>Arachidonoyl-<wbr></wbr>L-<wbr></wbr>serine (ARA-<wbr></wbr>S) is one such recently isolated endocannabinoid with an unusual activity profile. ARA-<wbr></wbr>S does not bind to central cannabinoid (CB<sub>1</sub>) and peripheral cannabinoid (CB<sub>2</sub>) receptors or vanilloid receptor 1 (VR1). Like cannabidiol, ARA-<wbr></wbr>S (5 mg/kg) antagonizes the hypotensive effects of a 10 mg/kg IV bolus of abnormal cannabidiol (Abn-<wbr></wbr>CBD) in an anesthetized rat blood pressure model. However, similar to Abn-<wbr></wbr>CBD, ARA-<wbr></wbr>S relaxes isolated rat mesenteric arteries and abdominal aorta as well as increases phosphorylation of Akt and mitogen-<wbr></wbr>activated protein kinase (MAPK) in HUVEC. The precise mechanisms of action by ARA-<wbr></wbr>S and Abn-<wbr></wbr>DBD in various vascular preparations appears to be different and requires further investigation.
| Catalog Number | R036064 |
| CAS Number | 187224-29-9 |
| Synonyms | N-[(5Z,8Z,11Z,14Z)-1-Oxo-5,8,11,14-eicosatetraen-1-yl]-L-serine; N-Arachidonoylserine? |
| Molecular Formula | C23H37NO4 |
| Purity | ≥95% |
| Storage | -20°C |
| InChIKey | FQUVPTVNRMUOPO-DOFZRALJSA-N |
