For research use only. Not for therapeutic Use.
N-Benzyl-N-bis-PEG2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
| Catalog Number | I015880 |
| CAS Number | 119580-47-1 |
| Synonyms | 2-[2-[benzyl-[2-(2-hydroxyethoxy)ethyl]amino]ethoxy]ethanol |
| Molecular Formula | C15H25NO4 |
| Purity | ≥95% |
| InChI | InChI=1S/C15H25NO4/c17-8-12-19-10-6-16(7-11-20-13-9-18)14-15-4-2-1-3-5-15/h1-5,17-18H,6-14H2 |
| InChIKey | HBHHHXUOMCTWCK-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)CN(CCOCCO)CCOCCO |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
