For research use only. Not for therapeutic Use.
N-Boc-dolaproine-methyl is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580). Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity[1].
| Catalog Number | I040496 |
| CAS Number | 164456-57-9 |
| Synonyms | tert-butyl (2S)-2-[(1R,2R)-1-hydroxy-3-methoxy-2-methyl-3-oxopropyl]pyrrolidine-1-carboxylate |
| Molecular Formula | C14H25NO5 |
| Purity | ≥95% |
| InChI | InChI=1S/C14H25NO5/c1-9(12(17)19-5)11(16)10-7-6-8-15(10)13(18)20-14(2,3)4/h9-11,16H,6-8H2,1-5H3/t9-,10+,11-/m1/s1 |
| InChIKey | YESVEVMVKPHDFA-OUAUKWLOSA-N |
| SMILES | CC(C(C1CCCN1C(=O)OC(C)(C)C)O)C(=O)OC |
| Reference | [1]. Almeida W P, et al. An easy and stereoselective synthesis of N-Boc-dolaproine via the Baylis–Hillman reaction[J]. Tetrahedron letters, 2003, 44(5): 937-940. |
