N-Boc-N-bis(PEG2-propargyl)

• CAT Number: I014507
• CAS Number: 2100306-86-1
• Molecular Formula: C19H31NO6
• Molecular Weight: 369.45
• Purity: ≥95%
• Synonyms: tert-butyl N,N-bis[2-(2-prop-2-ynoxyethoxy)ethyl]carbamate
• InChI: InChI=1S/C19H31NO6/c1-6-10-22-14-16-24-12-8-20(18(21)26-19(3,4)5)9-13-25-17-15-23-11-7-2/h1-2H,8-17H2,3-5H3
• InChIKey: NSGYNRBYZCGGOL-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)N(CCOCCOCC#C)CCOCCOCC#C

N-Boc-N-bis(PEG2-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-Boc-N-bis(PEG2-propargyl) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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