For research use only. Not for therapeutic Use.
N-Boc-PEG5-alcohol is a polyethylene glycol (PEG)-based PROTAC linker utilized in the synthesis of proteolysis-targeting chimeras (PROTACs). This linker consists of a PEG chain with five ethylene glycol units, terminated with an alcohol group and protected by a Boc (tert-butoxycarbonyl) group. It serves as a flexible spacer between the ligand targeting the protein of interest and the ligand recruiting an E3 ubiquitin ligase. N-Boc-PEG5-alcohol enables the construction of PROTAC molecules, facilitating targeted protein degradation and enhancing therapeutic potential in drug development and chemical biology research.
| Catalog Number | I016598 |
| CAS Number | 1404111-67-6 |
| Molecular Formula | C₁₅H₃₁NO₇ |
| Purity | ≥95% |
| Target | PROTAC Linkers |
| IUPAC Name | tert-butyl N-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethyl]carbamate |
| InChI | InChI=1S/C15H31NO7/c1-15(2,3)23-14(18)16-4-6-19-8-10-21-12-13-22-11-9-20-7-5-17/h17H,4-13H2,1-3H3,(H,16,18) |
| InChIKey | PBWLVPPLXJCLBC-UHFFFAOYSA-N |
| SMILES | CC(C)(C)OC(=O)NCCOCCOCCOCCOCCO |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
