N-Boc-PEG5-bromide

• CAT Number: I017174
• CAS Number: 1392499-32-9
• Molecular Formula: C₁₅H₃₀BrNO₆
• Molecular Weight: 400.31
• Purity: ≥95%
• Target: PROTAC
• IUPAC Name: tert-butyl N-[2-[2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethoxy]ethyl]carbamate
• InChI: InChI=1S/C15H30BrNO6/c1-15(2,3)23-14(18)17-5-7-20-9-11-22-13-12-21-10-8-19-6-4-16/h4-13H2,1-3H3,(H,17,18)
• InChIKey: KYOVSWOWVSWAII-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)NCCOCCOCCOCCOCCBr

N-Boc-PEG5-bromide（Cat No.:I017174） is a linker compound based on PEG (polyethylene glycol), alkyl, and ether components, commonly employed in the synthesis of PROTACs (proteolysis-targeting chimeras). PROTACs are bifunctional molecules designed to recruit target proteins for degradation via the ubiquitin-proteasome system. N-Boc-PEG5-bromide serves as a cleavable ADC (antibody-drug conjugate) linker in the construction of ADCs, which are antibody-based therapeutics designed to selectively deliver cytotoxic drugs to target cells, enhancing their specificity and therapeutic efficacy. This linker facilitates the release of the drug payload within the targeted cells, leading to their destruction.

Reference

[1]. Carston R. Wagner, et al. Protein nanorings. US8236925B1.