N-Boc-PEG7-alcohol

• CAT Number: I016984
• CAS Number: 1292268-13-3
• Molecular Formula: C₁₉H₃₉NO₉
• Molecular Weight: 425.51
• Purity: ≥95%
• Target: PROTAC
• IUPAC Name: 4,6-dimorpholin-4-yl-N-(4-nitrophenyl)-1,3,5-triazin-2-amine
• InChI: InChI=1S/C17H21N7O4/c25-24(26)14-3-1-13(2-4-14)18-15-19-16(22-5-9-27-10-6-22)21-17(20-15)23-7-11-28-12-8-23/h1-4H,5-12H2,(H,18,19,20,21)
• InChIKey: MSSXBKQZZINCRI-UHFFFAOYSA-N
• SMILES: C1COCCN1C2=NC(=NC(=N2)NC3=CC=C(C=C3)[N+](=O)[O-])N4CCOCC4

N-Boc-PEG7-alcohol（Cat No.:I016984） is a PROteolysis Targeting Chimera (PROTAC) bridge that falls under the PEG (Polyethylene glycol) class and Alkyl/Ether class. It serves as a versatile building block for the synthesis of various PROTAC molecules. Additionally, N-Boc-PEG7-alcohol is a cleavable antibody-drug conjugate (ADC) linker used in the construction of ADCs. Its inclusion allows for the controlled release of the attached drug, enhancing the targeted delivery and efficacy of the therapeutic payload in the context of antibody-based therapies.

Reference

[1]. Julie Moreau, et al. Modular Synthesis of Bifunctional Linkers for Materials Science. European Journal of OrganicChemistry , 2011 ( 9 ) , 1641-1644.