N-Boc-PEG9-alcohol

• CAT Number: I016703
• CAS Number: 2112731-44-7
• Molecular Formula: C₂₃H₄₇NO₁₁
• Molecular Weight: 513.62
• Purity: ≥95%
• Target: PROTAC

N-Boc-PEG9-alcohol(CAT: I016703) is a versatile compound used as a linker in the synthesis of PROTACs (PROteolysis TAgeting Chimeras) and antibody-drug conjugates (ADCs). With its polyethylene glycol (PEG) and alkyl/ether moieties, N-Boc-PEG9-alcohol provides a strategic connection between different molecular components. In PROTACs, this linker helps bridge the gap between the target protein binder and the ubiquitin ligase recruiter, facilitating targeted protein degradation. In ADCs, N-Boc-PEG9-alcohol serves as a cleavable linker that enables the controlled release of potent cytotoxic agents specifically within targeted cells, enhancing the therapeutic effect while minimizing off-target effects.

Reference

[1]. Nello Mainolfi, wt al. Irak degraders and uses thereof. US20190192668A1.