For research use only. Not for therapeutic Use.
Quorum sensing is a regulatory process used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production, release, and detection of small diffusible signal molecules called autoinducers. The N-<wbr></wbr>acylated homoserine lactones (AHLs) comprise one such class of autoinducers, each of which generally consists of a fatty acid coupled with homoserine lactone (HSL). AHLs vary in acyl group length (C<sub>4</sub>-<wbr></wbr>C<sub>18</sub>), in the substitution of C3 (hydrogen, hydroxyl, or oxo group) and in the presence or absence of one or more carbon-<wbr></wbr>carbon double bonds in the fatty acid chain. These differences confer signal specificity through the affinity of transcriptional regulators of the LuxR family. C18:1-<wbr></wbr>Δ and thus, might be used to inhibit pathogenesis by regulating bacerial quorum sensing signaling.
| Catalog Number | R041815 |
| CAS Number | 1400974-23-3 |
| Synonyms | C18:1-Δ9 cis-(L)-HSL;N-(2-oxotetrahydrofuran-3S-yl) Oleyl Amide |
| Molecular Formula | C22H39NO3 |
| Purity | ≥95% |
| Target | Bacterial |
| Storage | -20°C |
| InChI | InChI=1S/C22H39NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(24)23-20-18-19-26-22(20)25/h9-10,20H,2-8,11-19H2,1H3,(H,23,24)/b10-9-/t20-/m0/s1 |
| InChIKey | PYEKBLYUYSJMKS-QJRAZLAKSA-N |
| SMILES | CCCCCCCC/C=CCCCCCCCC(=O)N[C@H]1CCOC1=O |
| Reference | 1.González, J.E., and Keshavan, N.D. Messing with bacterial quorum sensing. Microbiology and Molecular Biology Reviews 70(4), 859-875 (2006). |
