For research use only. Not for therapeutic Use.
<p>It is a selective blocker of the TTX-sensitive Na<sup>+</sup> channel in the heart, a potent antiarrhythmic belonging to the I<span style=/font-size: 8.33333px;/>d</br><p><strong>N-Deacetyllappaconitine</strong> possesses a potent anti-arrhythmic and antifibrillatory action in various forms of extrasystolic and systolic arrhythmias. 0.5-1 mg/kg (i.v.) prevent and stop arrhythmias induced by <strong>Aconitine</strong>, Ba chloride, electric stimulation and occlusion of the coronary artery. Comparatively to many antiarrhythmic drugs, at the dosage producing a strong antiarrhytmic effect, it does not lower the systemic arterial pressure, does not possess negative and inotropic or chronotropic action and slightly acts upon the refractory period and the Q-T interval.<br /><br /><strong> N-Deacetyllappaconitine</strong> interacts selectively with TTX-sensitive Na<sup>+</sup> channel and suppresses the Na<sup>+</sup> current without changing the channel activation threshold, which has been established using patch clamp and intracellular perfusion on isolated cardiomyocytes and neurons from rat ganglia. <br />It has also been established that <strong>N-Deacetyllappaconitine</strong> acts as a local anaesthetic and as an anti-inflammatory.</p></br>
| Catalog Number | M065790 |
| CAS Number | 11033-64-0 |
| Molecular Formula | C30H42N2O7 |
| Purity | ≥95% |
| Storage | -20°C |
| Reference | – Dzjakhangirov et al. Rept. Acad. Sci. UzSSR (1990) (Russian). 8:44-48<br /><br /><br /><br /> |
