For research use only. Not for therapeutic Use.
N-Demethyl MK-6884 (compound 34) is a potent M4 mAChR allosteric modulator. N-Demethyl MK-6884 can be used in the studies of alzheimer’s disease and other diseases mediated by the M4 mAChR[1].
| Catalog Number | I042751 |
| CAS Number | 2102194-36-3 |
| Synonyms | 5-[1-[(1-methylcyclopentyl)methyl]pyrazol-4-yl]-6-(3-oxo-1,2-dihydroisoindol-5-yl)pyridine-2-carbonitrile |
| Molecular Formula | C24H23N5O |
| Purity | ≥95% |
| InChI | InChI=1S/C24H23N5O/c1-24(8-2-3-9-24)15-29-14-18(13-27-29)20-7-6-19(11-25)28-22(20)16-4-5-17-12-26-23(30)21(17)10-16/h4-7,10,13-14H,2-3,8-9,12,15H2,1H3,(H,26,30) |
| InChIKey | UJZZUFNAQWAFMJ-UHFFFAOYSA-N |
| SMILES | CC1(CCCC1)CN2C=C(C=N2)C3=C(N=C(C=C3)C#N)C4=CC5=C(CNC5=O)C=C4 |
| Reference | [1]. John J. Acton, et al. 3- (1h-pyrazol-4-yl) pyridineallosteric modulators of the m4 muscarinic acetylcholine receptor. Patent WO2017107089A1. |
