N-Desethyl amodiaquine

• CAT Number: I019000
• CAS Number: 79352-78-6
• Molecular Formula: C₁₈H₁₈ClN₃O
• Molecular Weight: 327.81
• Purity: ≥95%
• IUPAC Name: 4-[(7-chloroquinolin-4-yl)amino]-2-(ethylaminomethyl)phenol
• InChI: InChI=1S/C18H18ClN3O/c1-2-20-11-12-9-14(4-6-18(12)23)22-16-7-8-21-17-10-13(19)3-5-15(16)17/h3-10,20,23H,2,11H2,1H3,(H,21,22)
• InChIKey: VRXFDHAGFYWGHT-UHFFFAOYSA-N
• SMILES: CCNCC1=C(C=CC(=C1)NC2=C3C=CC(=CC3=NC=C2)Cl)O

N-Desethyl Amodiaquine（Cat No.:I019000）is the primary active metabolite of amodiaquine, an antimalarial drug widely used to treat Plasmodium falciparum malaria. This metabolite is responsible for much of the drug’s therapeutic activity, as it inhibits the parasite’s heme detoxification process, leading to its death. N-Desethyl Amodiaquine exhibits a longer half-life and greater potency than its parent compound, contributing to sustained antimalarial effects. It is commonly studied in pharmacokinetic and pharmacodynamic research to improve malaria treatments and understand resistance mechanisms. Its role is crucial in advancing antimalarial drug development.

Reference

[1]. Sasi P, et al. In vivo and in vitro efficacy of amodiaquine against Plasmodium falciparum in an area of continued use of 4-aminoquinolines in East Africa. J Infect Dis. 2009 Jun 1;199(11):1575-82.