For research use only. Not for therapeutic Use.
N-Desethyl vardenafil (Cat No.: R006137) is the primary active metabolite of vardenafil, a phosphodiesterase type 5 (PDE5) inhibitor used to treat erectile dysfunction and pulmonary arterial hypertension. It is formed in the body after vardenafil is metabolized and has similar pharmacological properties, contributing to the drug’s therapeutic effects. By inhibiting PDE5, N-desethyl vardenafil helps relax blood vessels in the penis and lungs, enhancing blood flow. This metabolite’s potency and pharmacokinetics are important factors in understanding the drug’s overall efficacy and duration of action.
| CAS Number | 448184-46-1 |
| Synonyms | 2-(2-ethoxy-5-piperazin-1-ylsulfonylphenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one |
| Molecular Formula | C21H28N6O4S |
| Purity | ≥95% |
| InChI | InChI=1S/C21H28N6O4S/c1-4-6-18-23-14(3)19-21(28)24-20(25-27(18)19)16-13-15(7-8-17(16)31-5-2)32(29,30)26-11-9-22-10-12-26/h7-8,13,22H,4-6,9-12H2,1-3H3,(H,24,25,28) |
| InChIKey | OKUKNGDVADFTHE-UHFFFAOYSA-N |
| SMILES | CCCC1=NC(=C2N1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCNCC4)OCC)C |
| Reference | [1]. Bartošová Z, et al. High-performance liquid chromatographic method with amperometric detection employing boron-doped diamond electrode for the determination of sildenafil, vardenafil and their main metabolites in plasma. J Chromatogr A. 2011 Nov 4;1218(44):7996-8001. [2]. Strano-Rossi S, et al. A gas chromatography/mass spectrometry method for the determination of sildenafil, vardenafil and tadalafil and their metabolites in human urine. Rapid Commun Mass Spectrom. 2010 Jun 15;24(11):1697-706. |
