N-Desmethyl-PK 11195

• CAT Number: I047631
• CAS Number: 124236-61-9
• Molecular Formula: C20H19ClN2O
• Molecular Weight: 338.83
• Purity: ≥95%
• IUPAC Name: N-butan-2-yl-1-(2-chlorophenyl)isoquinoline-3-carboxamide
• InChI: InChI=1S/C20H19ClN2O/c1-3-13(2)22-20(24)18-12-14-8-4-5-9-15(14)19(23-18)16-10-6-7-11-17(16)21/h4-13H,3H2,1-2H3,(H,22,24)
• SMILES: CCC(C)NC(=O)C1=CC2=CC=CC=C2C(=N1)C3=CC=CC=C3Cl

Precursor for [N-methyl-11C]PK 11195 for PET studies. Radioligand precursor of the peripheral benzodiazepine antagonist PK 11195 (Axon 1208).
R-enantiomer precursor  (R)-(-)-N-Desmethyl-PK 11195 is  available as Axon 2784 and the R-enantiomer of PK 11195 is available as Axon 2785.
KEYWORDS: N-Desmethyl-PK 11195 | supplier | PK 11195 radioligand precursor | N-Desmethyl-PK11195 | N-Desmethyl-PK-11195 | CAS [124236-61-9] | GABA | GABA-A | Antagonist | Ion Channels | PET

Reference

F Shah et al. Synthesis of the enantiomers of [N-methyl-11C]PK 11195 and comparison of their behaviours as radioligands for PK binding sites in rats. Nucl Med Biol. 1994 May;21(4):573-81.