N-Desmethylclozapine-d8 hydrochloride

• CAT Number: S000463
• CAS Number: 2705402-91-9
• Molecular Formula: C17H10D8Cl2N4
• Molecular Weight: 357.31
• Purity: ≥95%
• Target: Neuronal Signaling
• IUPAC Name: 3-chloro-6-(2,2,3,3,5,5,6,6-octadeuteriopiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine;hydrochloride
• InChI: InChI=1S/C17H17ClN4.ClH/c18-12-5-6-15-16(11-12)21-17(22-9-7-19-8-10-22)13-3-1-2-4-14(13)20-15;/h1-6,11,19-20H,7-10H2;1H/i7D2,8D2,9D2,10D2
• InChIKey: BZUSJYSTHWCMAS-SJEKSWIZSA-N
• SMILES: C1CN(CCN1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42.Cl

N-Desmethylclozapine-d8 hydrochloride（Cat No.:S000463） is a deuterated form of N-desmethylclozapine, where eight hydrogen atoms are replaced with deuterium, enhancing its stability and making it useful for pharmacokinetic and metabolic research. N-desmethylclozapine is an active metabolite of clozapine, an atypical antipsychotic used primarily to treat schizophrenia. It contributes to the therapeutic effects and side effects of clozapine, including its unique efficacy in treatment-resistant schizophrenia. The hydrochloride salt form improves solubility. The deuterated variant, N-Desmethylclozapine-d8 hydrochloride, allows for detailed studies of the metabolite’s behavior, metabolism, and its interaction with various biological systems.