N-Desmethylclozapine-d8

• CAT Number: S000424
• CAS Number: 1189888-77-4
• Molecular Formula: C17H9D8ClN4
• Molecular Weight: 320.85
• Purity: ≥95%
• IUPAC Name: 3-chloro-6-(2,2,3,3,5,5,6,6-octadeuteriopiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine
• InChI: InChI=1S/C17H17ClN4/c18-12-5-6-15-16(11-12)21-17(22-9-7-19-8-10-22)13-3-1-2-4-14(13)20-15/h1-6,11,19-20H,7-10H2/i7D2,8D2,9D2,10D2
• InChIKey: JNNOSTQEZICQQP-UFBJYANTSA-N
• SMILES: C1CN(CCN1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42

N-desmethylclozapine-d8（Cat No.:S000424） is a deuterated version of N-desmethylclozapine, where eight hydrogen atoms are replaced with deuterium, enhancing its stability for more detailed pharmacokinetic and metabolic research. N-desmethylclozapine is an active metabolite of clozapine, an antipsychotic medication used primarily for treatment-resistant schizophrenia. It contributes significantly to the therapeutic effects and side effects of clozapine, including antipsychotic efficacy and potentially fewer metabolic side effects compared to its parent compound. The deuterated version, N-Desmethylclozapine-d8, provides insights into the drug’s metabolism and interactions, aiding in the development of better therapeutic strategies.