N-Desmethyltamoxifen

• CAT Number: I017394
• CAS Number: 31750-48-8
• Molecular Formula: C25H27NO
• Molecular Weight: 357.49
• Purity: ≥95%
• Storage: 3 years -20°C powder
• SMILES: CC/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)/C3=CC=C(OCCNC)C=C3

N-Desmethyltamoxifen, the major metabolite of Tamoxifen in humans and a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen, also is a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation.

Reference

[1] Vertosick FT Jr, et al. J Neurooncol. 1994;19(2):97-103.
[2] Morad SA, et al. Biochim Biophys Acta. 2015 Jul;1851(7):919-28.