N-dodecanoyl-L-Homoserine lactone

• CAT Number: M140600
• CAS Number: 137173-46-7
• Molecular Formula: C16H29NO3
• Molecular Weight: 283.41
• Purity: ≥95%
• Synonyms: N-[(3S)-2-oxooxolan-3-yl]dodecanamide
• InChI: InChI=1S/C16H29NO3/c1-2-3-4-5-6-7-8-9-10-11-15(18)17-14-12-13-20-16(14)19/h14H,2-13H2,1H3,(H,17,18)/t14-/m0/s1
• InChIKey: WILLZMOKUUPJSL-AWEZNQCLSA-N
• SMILES: CCCCCCCCCCCC(=O)NC1CCOC1=O

N-dodecanoyl-L-Homoserine lactone (C12-HSL) is a quorum sensing (QS) signaling molecule. N-dodecanoyl-L-Homoserine lactone (C12-HSL) aptamers blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa[1].
Disruption of cell-cell communication or quorum sensing (QS) is considered a stimulating approach for reducing bacterial pathogenicity and resistance[1].

Reference

[1]. Borges A, et al. Furvina inhibits the 3-oxo-C12-HSL-based quorum sensing system of Pseudomonas aeruginosa and QS-dependent phenotypes. Biofouling. 2017 Feb;33(2):156-168.
 [Content Brief]