N-Ethyl tadalafil

• CAT Number: I033204
• CAS Number: 1609405-34-6
• Molecular Formula: C21H23NO2
• Molecular Weight: 321.42
• Purity: 98%
• Synonyms: N-Ethyl tadalafil; NEthyl tadalafil; Homotadalafil
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: (6R,12aR)-6-(benzo[d][1,3]dioxol-5-yl)-2-ethyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione
• InChI: InChI=1S/C23H21N3O4/c1-2-25-11-20(27)26-17(23(25)28)10-15-14-5-3-4-6-16(14)24-21(15)22(26)13-7-8-18-19(9-13)30-12-29-18/h3-9,17,22,24H,2,10-12H2,1H3/t17-,22-/m1/s1
• InChIKey: QGNIMKVVHAXCSK-VGOFRKELSA-N
• SMILES: O=C([C@@]1([H])CC2=C([C@@H](C3=CC=C(OCO4)C4=C3)N15)NC6=C2C=CC=C6)N(CC)CC5=O

N-Ethyl tadalafil (Cat No.: I033204) is a structural analog of tadalafil, a well-known phosphodiesterase type 5 (PDE5) inhibitor used to treat erectile dysfunction and pulmonary arterial hypertension. The N-ethyl modification alters its pharmacokinetic or pharmacodynamic properties, potentially affecting potency, selectivity, or duration of action. Like tadalafil, it may enhance nitric oxide–mediated vasodilation by inhibiting PDE5, leading to increased cyclic GMP levels. N-Ethyl tadalafil is primarily studied in pharmaceutical research to explore structure-activity relationships and develop novel PDE5 inhibitors with improved therapeutic profiles.