For research use only. Not for therapeutic Use.
N-Fmoc-N,O-dimethyl-L-serine is a serine derivative that can be used for coibamide A synthesis. Coibamide A is a marine natural product with potent antiproliferative activity against human cancer cells[1][2].
| Catalog Number | I043244 |
| CAS Number | 1569103-64-5 |
| Synonyms | (2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-methoxypropanoic acid |
| Molecular Formula | C20H21NO5 |
| Purity | ≥95% |
| InChI | InChI=1S/C20H21NO5/c1-21(18(12-25-2)19(22)23)20(24)26-11-17-15-9-5-3-7-13(15)14-8-4-6-10-16(14)17/h3-10,17-18H,11-12H2,1-2H3,(H,22,23)/t18-/m0/s1 |
| InChIKey | CTHCRMIWFPLNJK-SFHVURJKSA-N |
| SMILES | CN(C(COC)C(=O)O)C(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13 |
| Reference | [1]. Yao G, et al. Efficient Synthesis and Stereochemical Revision of Coibamide A. J Am Chem Soc. 2015 Oct 28;137(42):13488-91. [2]. Tranter D, et al. Coibamide A Targets Sec61 to Prevent Biogenesis of Secretory and Membrane Proteins. ACS Chem Biol. 2020 Aug 21;15(8):2125-2136. |
