N-Formyl-Met-Leu-Phe

• CAT Number: P000134
• CAS Number: 59880-97-6
• Molecular Formula: C21H31N3O5S
• Molecular Weight: 437.55
• Purity: ≥95%
• Synonyms: Alternative Name: fMLP
• Target: TNF Receptor
• Solubility: Soluble to 4.38 mg/ml in DMSO
• Storage: Desiccate at -20℃
• IUPAC Name: (2S)-2-[[(2S)-2-[[(2S)-2-formamido-4-methylsulfanylbutanoyl]amino]-4-methylpentanoyl]amino]-3-phenylpropanoic acid
• InChI: 1S/C21H31N3O5S/c1-14(2)11-17(23-19(26)16(22-13-25)9-10-30-3)20(27)24-18(21(28)29)12-15-7-5-4-6-8-15/h4-8,13-14,16-18H,9-12H2,1-3H3,(H,22,25)(H,23,26)(H,24,27)(H,28,29)/t16-,17-,18-/m0/s1
• InChIKey: PRQROPMIIGLWRP-BZSNNMDCSA-N
• SMILES: CC(C)C[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)O)NC(=O)[C@H](CCSC)NC=O

N-Formyl-Met-Leu-Phe (fMLP) (Cat No.: P000134) is a synthetic peptide that mimics the N-terminal structure of bacterial proteins, acting as a potent chemoattractant for immune cells, particularly neutrophils. It binds to formyl peptide receptors (FPRs) on leukocytes, triggering their migration to sites of infection or injury. fMLP is commonly used in research to study immune responses, inflammation, and the activation of immune cell signaling pathways. It has also been used as a model for understanding host-pathogen interactions and immune cell recruitment.