N-Me-N-bis-PEG4

• CAT Number: I015887
• CAS Number: 2055046-22-3
• Molecular Formula: C17H37NO8
• Molecular Weight: 383.48
• Purity: ≥95%
• Synonyms: 2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl-methylamino]ethoxy]ethoxy]ethoxy]ethanol
• InChI: InChI=1S/C17H37NO8/c1-18(2-6-21-10-14-25-16-12-23-8-4-19)3-7-22-11-15-26-17-13-24-9-5-20/h19-20H,2-17H2,1H3
• InChIKey: OFUZCSHYMKKGIL-UHFFFAOYSA-N
• SMILES: CN(CCOCCOCCOCCO)CCOCCOCCOCCO

N-Me-N-bis-PEG4 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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