N-methyl-N-dithiocarboxyglucamine sodium

• CAT Number: R011915
• CAS Number: 91840-27-6
• Molecular Formula: C8H16NNaO5S2
• Molecular Weight: 293.34
• Purity: ≥95%
• Synonyms: sodium;N-methyl-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]carbamodithioate
• InChI: InChI=1S/C8H17NO5S2.Na/c1-9(8(15)16)2-4(11)6(13)7(14)5(12)3-10;/h4-7,10-14H,2-3H2,1H3,(H,15,16);/q;+1/p-1/t4-,5+,6+,7+;/m0./s1
• InChIKey: PLQRBFAACWRSKF-LJTMIZJLSA-M
• SMILES: CN(CC(C(C(C(CO)O)O)O)O)C(=S)[S-].[Na+]

N-methyl-N-dithiocarboxyglucamine (MDCG) sodium mobilizes and promotes excretion of metallothionein-bound 109Cd in mouse model. N-methyl-N-dithiocarboxyglucamine significantly lowers the Cd content of both the liver and kidney, which is organs most susceptible to Cd-induced toxicity[1].
N-methyl-N-dithiocarboxyglucamine (1.1 mM/kg; ip; single dose) could significantly induce the excretion of Cd from feces. Increasing the number of treatments to 7 times per week, N-methyl-N-dithiocarboxyglucamine results in a more than 50% reduction in systemic Cd load in mice[1].

Reference

[1]. Gale GR, et al. Effects of sodium N-methyl-N-dithiocarboxyglucamine on cadmium distribution and excretion. Life Sci. 1984 Dec 17;35(25):2571-8.
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