N-Methyl-N-(trimethylsilyl)trifluoroacetamide-d9

• CAT Number: R013824
• CAS Number: 945623-67-6
• Molecular Formula: C6H12F3NOSi
• Molecular Weight: 208.303
• Purity: ≥95%
• Synonyms: 2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl-d9)acetamide; MSTFA; N-Methyl-N-(trimethyl-d9)silyltrifluoracetamide; NSC 339701-d9
• Storage: Room temperature
• IUPAC Name: 2,2,2-trifluoro-N-methyl-N-[tris(trideuteriomethyl)silyl]acetamide
• InChI: InChI=1S/C6H12F3NOSi/c1-10(12(2,3)4)5(11)6(7,8)9/h1-4H3/i2D3,3D3,4D3
• InChIKey: MSPCIZMDDUQPGJ-WVZRYRIDSA-N
• SMILES: CN(C(=O)C(F)(F)F)[Si](C)(C)C

N-Methyl-N-(trimethylsilyl)trifluoroacetamide-d9 (MSTFA-d9) is a deuterated form of a commonly used derivatizing agent in gas chromatography-mass spectrometry (GC-MS). In this compound, nine hydrogen atoms are replaced with deuterium, making it especially useful in analytical chemistry for precise tracking and differentiation during the analysis of volatile compounds. The deuterium labeling helps distinguish between derivatized analytes and the reagent in mass spectrometry, improving the accuracy of quantitative and qualitative analyses. Despite the isotopic substitution, MSTFA-d9 retains the same reactivity and efficacy in derivatization as its non-deuterated counterpart.