N'-Nitro-D-arginine

• CAT Number: I043248
• CAS Number: 66036-77-9
• Molecular Formula: C6H13N5O4
• Molecular Weight: 219.20
• Purity: ≥95%
• Synonyms: (2R)-2-amino-5-[[amino(nitramido)methylidene]amino]pentanoic acid
• InChI: InChI=1S/C6H13N5O4/c7-4(5(12)13)2-1-3-9-6(8)10-11(14)15/h4H,1-3,7H2,(H,12,13)(H3,8,9,10)/t4-/m1/s1
• InChIKey: MRAUNPAHJZDYCK-SCSAIBSYSA-N
• SMILES: C(CC(C(=O)O)N)CN=C(N)N[N+](=O)[O-]

N’-Nitro-D-arginine, a nitric oxide synthesis inhibitor, also is a vasodilator that relaxes the smooth muscles and increases blood flow to the penis, improving erections. N’-Nitro-D-arginine also inhibits neutrophil migration by blocking receptors for tumour necrosis factor alpha (TNFα) and interleukin 8 (IL8)[1].
N’-Nitro-D-arginine (40 mg/kg) produces a significant increase in systolic blood pressure in the chronic, awake, instrumented sheep model[1].

Reference

[1]. C K Narkowicz, et al. Delayed recovery from NG-nitro-L-arginine in the conscious sheep. Clin Exp Pharmacol Physiol. 1991 Dec;18(12):843-6.
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